Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

Chemoprevention has been considered as a possible approach for cancer prevention. A
significant effort has been made in the development of novel drugs for both cancer …

How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2
(PGE2) enhance colon cancer progression remains poorly understood. We show that PGE2 …

G protein-coupled receptors (GPCRs) play a central role in signal transmission, thereby
controlling many facets of cellular function. Overwhelming evidence now implicates GPCRs …