Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia

DE Surate Solaligue… - … of Physiology-Lung …, 2017 - journals.physiology.org
The objective of lung development is to generate an organ of gas exchange that provides
both a thin gas diffusion barrier and a large gas diffusion surface area, which concomitantly …

Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease

YS Prakash - American Journal of Physiology-Lung Cellular …, 2016 - journals.physiology.org
Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage

M Hurskainen, I Mižíková, DP Cook… - Nature …, 2021 - nature.com
During late lung development, alveolar and microvascular development is finalized to
enable sufficient gas exchange. Impaired late lung development manifests as …

Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs

M Syed, P Das, A Pawar, ZH Aghai, A Kaskinen… - Nature …, 2017 - nature.com
Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of
bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or …

[HTML][HTML] Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants

CV Lal, N Olave, C Travers, G Rezonzew, K Dolma… - JCI insight, 2018 - ncbi.nlm.nih.gov
Premature infants are at high risk for developing bronchopulmonary dysplasia (BPD),
characterized by chronic inflammation and inhibition of lung development, which we have …

Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia

C Nardiello, I Mižíková, DM Silva… - Disease models & …, 2017 - journals.biologists.com
Progress in developing new therapies for bronchopulmonary dysplasia (BPD) is sometimes
complicated by the lack of a standardised animal model. Our objective was to develop a …

Recent advances in the pathogenesis of BPD

RE Morty - Seminars in perinatology, 2018 - Elsevier
Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications
of preterm birth and is characterized histopathologically by impaired lung alveolarization …

Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence

MDA Paskeh, S Mirzaei, S Orouei, A Zabolian… - International Journal of …, 2021 - Elsevier
Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …

Looking ahead: where to next for animal models of bronchopulmonary dysplasia?

C Nardiello, I Mižíková, RE Morty - Cell and Tissue Research, 2017 - Springer
Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, with
appreciable morbidity and mortality in a neonatal intensive care setting. Much interest has …

Insulin‐like growth factor‐1 signaling in lung development and inflammatory lung diseases

Z Wang, W Li, Q Guo, Y Wang, L Ma… - BioMed research …, 2018 - Wiley Online Library
Insulin‐like growth factor‐1 (IGF‐1) was firstly identified as a hormone that mediates the
biological effects of growth hormone. Accumulating data have indicated the role of IGF‐1 …