Rapid advances in high-throughput sequencing and a growing realization of the importance
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …

Cancer progression and monotonic accumulation models were developed to discover
dependencies in the irreversible acquisition of binary traits from cross-sectional data. They …

Can we understand and predict the evolutionary pathways by which bacteria acquire multi-
drug resistance (MDR)? These questions have substantial potential impact in basic biology …

We present methods to construct phylogenetic models of tumor progression at the cellular
level that include copy number changes at the scale of single genes, entire chromosomes …

Motivation: Cancer development is driven by the accumulation of advantageous mutations
and subsequent clonal expansion of cells harbouring these mutations, but the order in which …

Background Cancer progression is caused by the sequential accumulation of mutations, but
not all orders of accumulation are equally likely. When the fixation of some mutations …

In genetics, many evolutionary pathways can be modeled by the ordered accumulation of
permanent changes. Mixture models of mutagenetic trees have been used to describe …

Background Disease progression models are important for understanding the critical steps
during the development of diseases. The models are imbedded in a statistical framework to …

Human tumours are often associated with the accumulation of chromosomal alterations in
the cancer cells. The identification of characteristic pathogenic routes improves prediction of …

Cancer progression is caused by the sequential accumulation of mutations, but not all
orders of accumulation of mutations are equally likely. When the fixation of some mutations …