Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Clinical decisions are more promising and evidence-based, hence, big data analytics to
assist clinical decision-making has been expressed for a variety of clinical fields. Due to the …

Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …

Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress
in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional …

Recent genomic studies have identified chromosomal rearrangements defining new
subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL), however many cases lack a …

INTRODUCTION The interaction among cell-autonomous circadian oscillators—daily cycles
of activity–rest and feeding–fasting—produces diurnal rhythms in gene expression in almost …

Enrichment analysis is a popular method for analyzing gene sets generated by genome-
wide experiments. Here we present a significant update to one of the tools in this domain …

Genomics, epigenomics, transcriptomics, proteomics and metabolomics efforts rapidly
generate a plethora of data on the activity and levels of biomolecules within mammalian …