Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with
mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that …

Many attempts have been made to localize the physical trace of a memory, or engram, in the
brain. However, until recently, engrams have remained largely elusive. In this Review, we …

Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

Objective Alzheimer disease (AD) is characterized by functional impairment in the neural
elements and circuits underlying cognitive and memory functions. We hypothesized that …

Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …

Background The medial temporal structures, including the hippocampus and the entorhinal
cortex, are critical for the ability to transform daily experience into lasting memories. We …

Recent advances in neuroscience have paved the way to innovative applications that
cognitively augment and enhance humans in a variety of contexts. This paper aims at …