Spinal afferent innervation of the colon and rectum
Despite their seemingly elementary roles, the colon and rectum undertake a variety of key
processes to ensure our overall wellbeing. Such processes are coordinated by the …
processes to ensure our overall wellbeing. Such processes are coordinated by the …
Advances in enteric neurobiology: the “brain” in the gut in health and disease
The enteric nervous system (ENS) is a large, complex division of the peripheral nervous
system that regulates many digestive, immune, hormonal, and metabolic functions. Recent …
system that regulates many digestive, immune, hormonal, and metabolic functions. Recent …
Gut enterochromaffin cells drive visceral pain and anxiety
Gastrointestinal (GI) discomfort is a hallmark of most gut disorders and represents an
important component of chronic visceral pain. For the growing population afflicted by irritable …
important component of chronic visceral pain. For the growing population afflicted by irritable …
Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity
Inflammatory and functional gastrointestinal disorders such as irritable bowel syndrome
(IBS) and obstructive bowel disorder (OBD) underlie the most prevalent forms of visceral …
(IBS) and obstructive bowel disorder (OBD) underlie the most prevalent forms of visceral …
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …
capillary permeability and blood flow to produce neurogenic inflammation,, but whether …
The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders
L Riehl, J Fürst, M Kress, N Rykalo - Frontiers in Neuroscience, 2024 - frontiersin.org
Increasing evidence links the gut microbiome and the nervous system in health and disease.
This narrative review discusses current views on the interaction between the gut microbiota …
This narrative review discusses current views on the interaction between the gut microbiota …
Spinal VGLUT3 lineage neurons drive visceral mechanical allodynia but not sensitized visceromotor reflexes
Visceral pain is among the most prevalent and bothersome forms of chronic pain, but their
transmission in the spinal cord is still poorly understood. Here, we conducted focal colorectal …
transmission in the spinal cord is still poorly understood. Here, we conducted focal colorectal …
[HTML][HTML] Unique neural circuit connectivity of mouse proximal, middle, and distal colon defines regional colonic motor patterns
A Nestor-Kalinoski, KM Smith-Edwards… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Colonic motor patterns have been described by a number of different
groups, but the neural connectivity and ganglion architecture supporting patterned motor …
groups, but the neural connectivity and ganglion architecture supporting patterned motor …
[HTML][HTML] Serotonergic control of gastrointestinal development, motility, and inflammation
Although it is most well-known for its roles in central nervous system (CNS) function, the vast
majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) …
majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) …
[HTML][HTML] The enteric nervous system for epithelial researchers: basic anatomy, techniques, and interactions with the epithelium
The intestinal epithelium does not function in isolation, but interacts with many components
including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium …
including the Enteric Nervous System (ENS). Understanding ENS and intestinal epithelium …