[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

L Smigielski, V Jagannath, W Rössler, S Walitza… - Molecular …, 2020 - nature.com
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder

CT Chiu, Z Wang, JG Hunsberger, DM Chuang - Pharmacological reviews, 2013 - ASPET
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

MicroRNAs in neuronal function and dysfunction

HI Im, PJ Kenny - Trends in neurosciences, 2012 - cell.com
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …

Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers

B Khavari, MJ Cairns - Cells, 2020 - mdpi.com
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …

MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects

NR Smalheiser, G Lugli, HS Rizavi, VI Torvik… - PloS one, 2012 - journals.plos.org
Background Recent studies suggest that alterations in expression of genes, including those
which regulate neural and structural plasticity, may be crucial in the pathogenesis of …

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

BH Miller, Z Zeier, L Xi, TA Lanz… - Proceedings of the …, 2012 - National Acad Sciences
Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular
abnormalities that may have a neurodevelopmental origin. MicroRNAs (miRNAs) are small …

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

MicroRNAs: key regulators in the central nervous system and their implication in neurological diseases

DD Cao, L Li, WY Chan - International journal of molecular sciences, 2016 - mdpi.com
MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …

miR-212/132 expression and functions: within and beyond the neuronal compartment

A Wanet, A Tacheny, T Arnould… - Nucleic acids …, 2012 - academic.oup.com
During the last two decades, microRNAs (miRNAs) emerged as critical regulators of gene
expression. By modulating the expression of numerous target mRNAs mainly at the post …