Limited osseointegration of current orthopedic biomaterials contributes to the failure of
implants such as arthroplasties, bone screws, and bone grafts, which present a large …

Bone regeneration materials (BRMs) bring us new sights into the clinical management bone
defects. With advances in BRMs technologies, new strategies are emerging to promote bone …

Background: Understanding the molecular features of bone repair and osseointegration may
aid in the development of therapeutics to improve implant outcomes. The purpose of this …

Polytraumatic injuries, specifically long bone fracture and traumatic brain injury (TBI),
frequently occur together. Clinical observation has long held that TBI can accelerate fracture …

Background Cell culture studies demonstrate the importance of β3 integrin in osteocyte
mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of …

Osteoinduction of calcium phosphate (CaP) ceramics has been widely confirmed and
accepted, but the underlying mechanism has not been fully elucidated. This study …

Integrins are cell surface receptors that connect extracellular matrix (ECM) components to
the actin cytoskeleton and transmit chemical and mechanical signals into the cells through …

Although bone repairs through a very efficient regenerative process in 90% of the patients,
many factors can cause delayed or impaired healing. To date, there are no reliable …

Cancer radiation therapy can cause skeletal complications, such as osteopenia and
osteoporosis. To understand the mechanism responsible for the skeletal complications, the …

ABSTRACT Integrin‐based (β3) attachments to the extracellular matrix (ECM) on osteocyte
cell processes have recently been proposed to play an important role in facilitating osteocyte …