Extracellular vesicles in fungi: past, present, and future perspectives

J Rizzo, ML Rodrigues, G Janbon - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical
research fields. Many studies have reported the existence of EVs in all types of living cells …

Extracellular vesicles in the fungi kingdom

M Liebana-Jordan, B Brotons, JM Falcon-Perez… - International Journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are membranous, rounded vesicles released by prokaryotic and
eukaryotic cells in their normal and pathophysiological states. These vesicles form a network …

Communication is key: extracellular vesicles as mediators of infection and defence during host–microbe interactions in animals and plants

H U. Stotz, D Brotherton, J Inal - FEMS microbiology reviews, 2022 - academic.oup.com
Extracellular vesicles (EVs) are now understood to be ubiquitous mediators of cellular
communication. In this review, we suggest that EVs have evolved into a highly regulated …

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

J Rizzo, SSW Wong, AD Gazi… - Journal of …, 2021 - Wiley Online Library
Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …

Extracellular vesicles regulate biofilm formation and yeast-to-hypha differentiation in Candida albicans

L Honorato, JFD de Araujo, CC Ellis, AC Piffer… - MBio, 2022 - Am Soc Microbiol
In this study, we investigated the influence of fungal extracellular vesicles (EVs) during
biofilm formation and morphogenesis in Candida albicans. Using crystal violet staining and …

Reciprocal modulation of ammonia and melanin production has implications for cryptococcal virulence

RP Baker, A Casadevall - Nature communications, 2023 - nature.com
The fungus Cryptococcus neoformans is the causative agent of cryptococcosis, a disease
that is uniformly lethal unless treated with antifungal drugs, yet current regimens are …

The emerging role of extracellular vesicles in fungi: A double-edged sword

Y Lai, B Jiang, F Hou, X Huang, B Ling, H Lu… - Frontiers in …, 2023 - frontiersin.org
Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Protective effect of fungal extracellular vesicles against murine candidiasis

G Vargas, L Honorato, AJ Guimarães… - Cellular …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) are lipid bilayered compartments released by virtually all living
cells, including fungi. Among the diverse molecules carried by fungal EVs, a number of …

Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles

W Chan, FWN Chow, CC Tsang, X Liu… - Emerging Microbes & …, 2022 - Taylor & Francis
Drug resistance derived from extracellular vesicles (EVs) is an increasingly important
research area but has seldom been described regarding fungal pathogens. Here, we …

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model

AC Colombo, A Rella, T Normile, LS Joffe, PM Tavares… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …