The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

The hippocampus plays key roles in cognition and affect and serves as a model system for
structure/function studies in animals. So far, its complex anatomy has challenged …

When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

Highlights•The nature of a memory trace, not its age, determines its hippocampal
dependence.•Remote memories rich in perceptual detail still engage the hippocampus …

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

The dentate gyrus–CA3 circuit of the hippocampus is continuously modified by the
integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged …

Humans can recollect past events in details (recollection) and/or know that an object,
person, or place has been encountered before (familiarity). During the last two decades …

Medial temporal lobe dependent cognitive functions are highly vulnerable to hypoxia in the
hippocampal region, yet little is known about the relationship between the richness of …

Prevailing theories of hippocampal function argue that memories are rapidly encoded by
non-overlapping memory traces. Concurrently, the hippocampus has been argued to …