The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

Since the discovery almost fifteen years ago that E2F transcription factors are key targets of
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …

Cell death in skeletal component cells, including chondrocytes, osteoblasts, and osteocytes,
plays roles in skeletal development, maintenance, and repair as well as in the pathogenesis …

The E2F transcription factor plays a pivotal role in the timely activation of gene expression
during mammalian cell cycle progression, whereas pRB and related proteins control cell …

Experimental data generated in the past year have further emphasized the essential role for
the E2F transcription factors in the regulation of cell proliferation. Genetic studies have …

Eventually to understand the integrated function of the cell cycle regulatory network, we must
organize the known interactions in the form of a diagram, map, and/or database. A diagram …

The activity of the E2F transcription factor is controlled by physical association with the
retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family …

Flavopiridol inhibits phosphokinases. Its activity is strongest on cyclin dependent kinases
(cdk-1,-2,-4,-6,-7) and less on receptor tyrosine kinases (EGFR), receptor associates …

In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly,
cyclin E-dependent Cdk2 positively regulate the G1-to S-phase transition, by …