Molecular mechanisms of dermal aging and antiaging approaches

JW Shin, SH Kwon, JY Choi, JI Na, CH Huh… - International journal of …, 2019 - mdpi.com
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During
the aging process, the dermis undergoes significant changes. Collagen, which is a major …

Bioactive compounds for skin health: A review

M Michalak, M Pierzak, B Kręcisz, E Suliga - Nutrients, 2021 - mdpi.com
Human skin is continually changing. The condition of the skin largely depends on the
individual's overall state of health. A balanced diet plays an important role in the proper …

Pathophysiology of premature skin aging induced by ultraviolet light

GJ Fisher, ZQ Wang, SC Datta, J Varani… - … England Journal of …, 1997 - Mass Medical Soc
Background Long-term exposure to ultraviolet irradiation from sunlight causes premature
skin aging (photoaging), characterized in part by wrinkles, altered pigmentation, and loss of …

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

S Mukherjee, A Date, V Patravale… - … interventions in aging, 2006 - Taylor & Francis
Aging of skin is an intricate biological process consisting of two types. While intrinsic or
chronological aging is an inevitable process, photoaging involves the premature aging of …

[HTML][HTML] Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally …

J Varani, RL Warner, M Gharaee-Kermani… - Journal of investigative …, 2000 - Elsevier
Damage to human skin due to ultraviolet light from the sun (photoaging) and damage
occurring as a consequence of the passage of time (chronologic or natural aging) are …

[HTML][HTML] Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors

TT Schug, DC Berry, NS Shaw, SN Travis, N Noy - Cell, 2007 - cell.com
Transcriptional activation of the nuclear receptor RAR by retinoic acid (RA) often leads to
inhibition of cell growth. However, in some tissues, RA promotes cell survival and …

Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin

V Jenning, A Gysler, M Schäfer-Korting… - European journal of …, 2000 - Elsevier
To evaluate the potential use of solid lipid nanoparticles (SLN) in dermatology and
cosmetics, glyceryl behenate SLN loaded with vitamin A (retinol and retinyl palmitate) and …

Skin lightening preparations and the hydroquinone controversy

ZD Draelos - Dermatologic therapy, 2007 - Wiley Online Library
Skin lightening preparations are widely used in dermatology by persons of all Fitzpatrick
skin types. Fitzpatrick skin types I–III require local pigment lightening for the treatment of …

A review of skin ageing and its medical therapy

BA Gilchrest - British journal of dermatology, 1996 - academic.oup.com
Intrinsic (chronological) skin ageing is characterized hy atrophy of the skin with loss of
elasticity and slowed metabolic activity. The superposition of environmental damage …

Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro

J Varani, D Spearman, P Perone, SEG Fligiel… - The American journal of …, 2001 - Elsevier
Type I and type III procollagen are reduced in photodamaged human skin. This reduction
could result from increased degradation by metalloproteinases and/or from reduced …