Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …

Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …

Infectious diseases caused by apicomplexan parasites remain a global public health threat.
The presence of multiple ligand‐binding sites in tubulin makes this protein an attractive …

The spiroindimicins are a unique class of chlorinated indole alkaloids characterized by three
heteroaromatic rings structured around a congested spirocyclic stereocenter. Here, we …

Microtubules and specialized microtubule-containing structures are assembled from
tubulins, an ancient superfamily of essential eukaryotic proteins. Here, we use bioinformatic …

Tubulin detyrosination has been implicated in various human disorders and is important for
regulating microtubule dynamics. While in most organisms this modification is restricted to α …

Leishmania spp. are obligate intracellular parasites that must be internalized by phagocytic
cells to evade immune responses and cause disease. The uptake of both Leishmania …

Cytoskeletal dynamics are essential for cellular homeostasis and development for both
metazoans and protozoans. The function of cytoskeletal elements in protozoans can diverge …

The development of resistance to current antimalarial therapies remains a significant source
of concern. To address this risk, new drugs with novel targets in distinct developmental …

Protozoan parasites cause life‐threatening infections in both humans and animals, including
agriculturally significant livestock. Available treatments are typically narrow spectrum and …