Controlled proteolysis underlies a vast diversity of protective and regulatory processes that
are of key importance to cell fate. The unique molecular architecture of the widely conserved …

The Gram-negative bacterial envelope is an essential interface between the intracellular
and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the …

Abstract Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses
against cytosolic double-stranded (ds) DNA arising from genotoxic stress and pathogen …

Proteolytic cleavage of proteins that are permanently or transiently associated with the
cytoplasmic membrane is crucially important for a wide range of essential processes in …

Protein quality control is vital for all living cells and sophisticated molecular mechanisms
have evolved to prevent the excessive accumulation of unfolded proteins. High-temperature …

Microorganisms live in fluctuating environments, requiring stress response pathways to
resist environmental insults and stress. These pathways dynamically monitor cellular status …

Bacteria are confronted with a multitude of stressors when occupying niches within the host.
These stressors originate from host defense mechanisms, other bacteria during niche …

Bacterial cells are frequently exposed to dramatic fluctuations in their environment, which
cause perturbation in protein homeostasis and lead to protein misfolding. Bacteria have …

The biogenesis of transmembrane β-barrels (outer membrane proteins, or OMPs) is an
elaborate multistep orchestration of the nascent polypeptide with translocases, barrel …

HtrA (High temperature requirement protease A) proteins that are primarily involved in
protein quality control belong to a family of serine proteases conserved from bacteria to …