Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Early identification of genetic risk factors for complex diseases can enable timely
interventions and prevent serious outcomes, including mortality. While the genetics …

The long delay before genomic technologies become available in low-and middle-income
countries is a concern from both scientific and ethical standpoints. Polygenic risk scores …

Background Observational studies have investigated the effect of serum lipids on kidney
function, but these findings are limited by confounding, reverse causation and have reported …

The expansion of people speaking Bantu languages is the most dramatic demographic
event in Late Holocene Africa and fundamentally reshaped the linguistic, cultural and …

The majority of polygenic risk scores (PRS)(also known as polygenic scores, genetic risk
scores or polygenic indexes) have been generated and optimized in peoples of European …

Background Chronic kidney disease is becoming more prevalent in Africa, and its genetic
determinants are poorly understood. Creatinine-based estimated glomerular filtration rate …

Building longitudinal population cohorts in Africa for coordinated research and surveillance
can influence the setting of national health priorities, lead to the introduction of appropriate …

Phenome-wide association studies (PheWAS) facilitate the discovery of associations
between a single genetic variant with multiple phenotypes. For variants which impact a …

Chronic kidney disease (CKD) affects about 850 million people worldwide and is projected
to be the fifth leading cause of death by 2040. Individuals from low-and middle-income …