This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Many protein folding diseases are intimately associated with accumulation of amyloid
aggregates. The amyloid materials formed by different proteins/peptides share many …

Alzheimer's disease is a common neurodegenerative, progressive, and fatal disorder.
Generation and deposition of amyloid beta (Aβ) peptides associate with its pathogenesis …

A hallmark of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide in
the brain. Considerable evidence suggests that soluble Aβ oligomers are responsible for the …

Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in
Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to …

The prion protein (PrPC) is a central player in neurodegenerative diseases, such as prion
diseases or Alzheimer's disease. In contrast to disease-promoting cell surface PrPC …

Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most
abundantly found in the outer membrane of neurons. Due to structural characteristics (a …

Senile plaques and neurofibrillary tangles are the principal histopathologic hallmarks of
Alzheimer disease. The essential constituents of these lesions are structurally abnormal …

Proteolytic processing of the cellular and disease-associated form of the prion protein leads
to generation of bioactive soluble prion protein fragments and modifies the structure and …