Genetics of circadian rhythms and sleep in human health and disease

JM Lane, J Qian, E Mignot, S Redline… - Nature Reviews …, 2023 - nature.com
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Genetic determinants of daytime napping and effects on cardiometabolic health

HS Dashti, I Daghlas, JM Lane, Y Huang… - Nature …, 2021 - nature.com
Daytime napping is a common, heritable behavior, but its genetic basis and causal
relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide …

The origins and evolution of sleep

AC Keene, ER Duboue - Journal of Experimental Biology, 2018 - journals.biologists.com
Sleep is nearly ubiquitous throughout the animal kingdom, yet little is known about how
ecological factors or perturbations to the environment shape the duration and timing of …

Cohort profile: the LIFE-adult-study

C Engel, K Wirkner, S Zeynalova… - International Journal …, 2023 - academic.oup.com
International Journal of Epidemiology, 2023, e66–e79 https://doi. org/10.1093/ije/dyac114
Advance Access Publication Date: 28 May 2022 Cohort Profile comprehensive molecular …

Genetics of sleep and insights into its relationship with obesity

HS Dashti, JM Ordovás - Annual Review of Nutrition, 2021 - annualreviews.org
Considerable recent advancements in elucidating the genetic architecture of sleep traits and
sleep disorders may provide insight into the relationship between sleep and obesity. Despite …

Potential genetic and epigenetic mechanisms in insomnia: A systematic review

L Palagini, PA Geoffroy, PR Gehrman… - Journal of Sleep …, 2023 - Wiley Online Library
Insomnia is a stress‐related sleep disorder conceptualised within a diathesis‐stress
framework, which it is thought to result from predisposing factors interacting with …

[HTML][HTML] Behaviour genetics and sleep: A narrative review of the last decade of quantitative and molecular genetic research in humans

JJ Madrid-Valero, AM Gregory - Sleep Medicine Reviews, 2023 - Elsevier
During the last decade quantitative and molecular genetic research on sleep has increased
considerably. New behavioural genetics techniques have marked a new era for sleep …

The genetics and genomics of asthma

SAG Willis-Owen, WOC Cookson… - Annual review of …, 2018 - annualreviews.org
Asthma is a common, clinically heterogeneous disease with strong evidence of heritability.
Progress in defining the genetic underpinnings of asthma, however, has been slow and …

Integrative modeling of accelerometry-derived sleep, physical activity, and circadian rhythm domains with current or remitted major depression

SJ Kang, A Leroux, W Guo, D Dey, MPF Strippoli… - JAMA …, 2024 - jamanetwork.com
Importance Accelerometry has been increasingly used as an objective index of sleep,
physical activity, and circadian rhythms in people with mood disorders. However, most prior …