Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application

T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

DNA functional materials assembled from branched DNA: design, synthesis, and applications

Y Dong, C Yao, Y Zhu, L Yang, D Luo… - Chemical Reviews, 2020 - ACS Publications
DNA is traditionally known as a central genetic biomolecule in living systems. From an
alternative perspective, DNA is a versatile molecular building-block for the construction of …

Photo‐Reduction with NIR Light of Nucleus‐Targeting PtIV Nanoparticles for Combined Tumor‐Targeted Chemotherapy and Photodynamic Immunotherapy

D Wei, Y Huang, B Wang, L Ma… - Angewandte Chemie …, 2022 - Wiley Online Library
The development of PtIV prodrugs which are selectively reduced within cancerous cells into
their PtII therapeutically active species has received increasing attention within the last …

Nanobodies: next generation of cancer diagnostics and therapeutics

EY Yang, K Shah - Frontiers in Oncology, 2020 - frontiersin.org
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …

Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Y Wang, Y Jiang, D Wei, P Singh, Y Yu, T Lee… - Nature biomedical …, 2021 - nature.com
In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits
any survival benefits conferred by the drug. Here we show that the convection-enhanced …

Tetrahedral DNA Nanostructure with Interferon Stimulatory DNA Delivers Highly Potent Toxins and Activates the cGAS‐STING Pathway for Robust Chemotherapy and …

L Zhang, Y Wang, J Karges, D Tang… - Advanced …, 2023 - Wiley Online Library
Tumor metastases and reoccurrences are considered the leading cause of cancer‐
associated deaths. While highly efficient treatments for the eradication of primary tumors …

A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance

F Li, H Sun, J Ren, B Zhang, X Hu, C Fang… - Nature …, 2022 - nature.com
Platinum (Pt) resistance in cancer almost inevitably occurs during clinical Pt-based
chemotherapy. The spontaneous nucleotide-excision repair of cancer cells is a …

Antibody‐incorporated nanomedicines for cancer therapy

SY Wu, FG Wu, X Chen - Advanced Materials, 2022 - Wiley Online Library
Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents

C Liu, L Guo, Y Wang, J Zhang, C Fu - Coordination Chemistry Reviews, 2023 - Elsevier
Nanomaterials have been extensively used for cancer therapy and diagnosis due to their
designability, multifunctionality, and unique in vivo distribution. Metal ions are increasingly …

Unraveling and overcoming platinum drug‐resistant cancer tumors with DNA nanostructures

Y Yu, L Zhang, Z Qin, J Karges… - Advanced Functional …, 2023 - Wiley Online Library
Abstract All chemotherapeutic treatments worldwide (> 50%) use platinum‐based
compounds. Despite their clinical success, an increasing number of platinum drug‐resistant …