Since osteosarcoma (OS) is an aggressive bone cancer with unknown molecular pathways
of etiology and pathophysiology, improving patient survival has long been a challenge. The …

Immunotherapy has seen tremendous strides in the last decade, acquiring a prominent
position at the forefront of cancer treatment since it has been proven to be efficacious for a …

Tissue microenvironments affect the functional states of cancer cells, but determining these
influences in vivo has remained a challenge. We present a quantitative high-resolution …

The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for
cancer. Current small animal models for most cancers are syngeneic or genetically …

Sarcomas are a rare heterogeneous group of malignant neoplasms of mesenchymal origin
which represent approximately 13% of all cancers in pediatric patients. The most prevalent …

Ferroptosis is a novel form of non-apoptotic cell death that mainly results from the iron-
dependent lethal accumulation of lipid peroxidation products. Here, we defined differentially …

Pediatric cancer, although rare, requires the most optimized treatment approach to obtain
high survival rates and minimize serious long-term side effects in early adulthood. 18F-FDG …

In this study, we explored the therapeutic potential of everolimus, an mTOR inhibitor, in a
patient-derived xenograft (PDX) of rhabdomyosarcoma, the most prevalent malignant …

Background Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and
osteosarcoma, represent a group of malignancies that significantly contribute to cancer …

Purpose A significant portion of parents of children diagnosed with sarcoma experience
excessive stress and anxiety disorder. This quality improvement project aimed to implement …