Buprenorphine possesses many unique attributes that make it a practical agent for adults
and adolescents with opioid use disorder (OUD) and/or acute or chronic pain. Sublingual …

Introduction Buprenorphine precipitated opioid withdrawal (BPOW) is an uncommon
complication of buprenorphine initiation in the emergency department (ED), but it can …

Objectives: Patients with opioid use disorder (OUD) can initiate buprenorphine without
requiring a withdrawal period through a low-dose (sometimes referred to as “micro …

Although expanding the availability of buprenorphine—a first-line pharmacotherapy for
opioid-use disorder (OUD)—has increased the capacity of healthcare systems to offer …

Objectives: Alternative transition protocols from methadone to buprenorphine in the
treatment of opioid use disorder (OUD) are needed to reduce the risk of precipitated …

Methadone, a full opioid agonist at the mu-, kappa-, and delta-receptor, and buprenorphine,
a partial agonist at the mu receptor, are first-line medications in opioid maintenance …

Background Consistent reports from health professionals suggest that heroin is commonly
used by patients undergoing opioid maintenance treatment (OMT) in France, potentially …

Background There is a great public health need to identify novel treatment strategies for
opioid use disorder (OUD) in order to reduce relapse and overdose. Noninvasive brain …

Background Precipitated opioid withdrawal (POW) after opioid antagonist administration can
be challenging to manage in the emergency department (ED), particularly if caused by a …

Background: Patients with opioid use disorder (OUD) who are managed on methadone
often require transition to buprenorphine therapy. Current recommendations require months …