Disorders of the enteric nervous system—a holistic view
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …
and closely resembles components and functions of the central nervous system. Although …
Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome
MI Pinto-Sanchez, GB Hall, K Ghajar, A Nardelli… - Gastroenterology, 2017 - Elsevier
Background & Aims Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but
little is known about their effects on psychiatric comorbidities. We performed a prospective …
little is known about their effects on psychiatric comorbidities. We performed a prospective …
Pathophysiology of irritable bowel syndrome
GJ Holtmann, AC Ford, NJ Talley - The lancet Gastroenterology & …, 2016 - thelancet.com
Traditionally, irritable bowel syndrome has been considered to be a disorder with no known
underlying structural or biochemical explanation, but this concept is likely to be outdated. In …
underlying structural or biochemical explanation, but this concept is likely to be outdated. In …
American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation
AC Ford, P Moayyedi, BE Lacy, AJ Lembo… - Official journal of the …, 2014 - journals.lww.com
METHODS We have conducted a series of systematic reviews on the efficacy of therapy in
IBS and CIC. There have been several systematic reviews of therapy for IBS and CIC …
IBS and CIC. There have been several systematic reviews of therapy for IBS and CIC …
Neuropeptides and the microbiota-gut-brain axis
P Holzer, A Farzi - Microbial endocrinology: the microbiota-gut-brain axis …, 2014 - Springer
Neuropeptides are important mediators both within the nervous system and between
neurons and other cell types. Neuropeptides such as substance P, calcitonin gene-related …
neurons and other cell types. Neuropeptides such as substance P, calcitonin gene-related …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Irritable bowel syndrome: a gut microbiota-related disorder?
Y Bhattarai, DA Muniz Pedrogo… - American Journal of …, 2017 - journals.physiology.org
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders.
Despite its prevalence, the pathophysiology of IBS is not well understood although multiple …
Despite its prevalence, the pathophysiology of IBS is not well understood although multiple …
Visceral pain
L Grundy, A Erickson, SM Brierley - Annual review of physiology, 2019 - annualreviews.org
Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
Immune activation in irritable bowel syndrome: what is the evidence?
J Aguilera-Lizarraga, H Hussein… - Nature Reviews …, 2022 - nature.com
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is
characterized by abdominal pain and an altered defecation pattern. It affects between 5 and …
characterized by abdominal pain and an altered defecation pattern. It affects between 5 and …