The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

Hypoxia induces a group of physiologically important genes such as erythropoietin and
vascular endothelial growth factor. These genes are transcriptionally up-regulated by …

The c-Myc oncoprotein is a transcription factor which is a critical regulator of cellular
proliferation. Deregulated expression of c-Myc is associated with many human cancers …

During the G 1 phase of the cell cycle, an E2F–RB complex represses transcription, via the
recruitment of histone deacetylase activity. Phosphorylation of RB at the G 1/S boundary …

Replication-selective oncolytic viruses constitute a rapidly evolving and new treatment
platform for cancer. Gene-deleted viruses have been engineered for tumor selectivity, but …

The human proto‐oncogene c‐myc encodes a highly unstable transcription factor that
promotes cell proliferation. Although the extreme instability of Myc plays an important role in …

The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

Experimental data generated in the past year have further emphasized the essential role for
the E2F transcription factors in the regulation of cell proliferation. Genetic studies have …

Previous work has established a role for p53 in triggering apoptosis in response to DNA
damage; p53 also induces apoptosis in response to deregulation of the Rb cell cycle …