Dysfunction of pancreatic δ cells contributes to the etiology of diabetes. Despite their
important role, human δ cells are scarce, limiting physiological studies and drug discovery …

Insulin-producing β-cells in pancreatic islets are regulated by systemic cues and, locally, by
adjacent islet hormone-producing 'non-β-cells'(namely α-cells, δ-cells and γ-cells). Yet …

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role
in the health of the host and the development of diseases. As a vital component of the …

Acromegaly is a rare endocrine disorder caused by excessive growth hormone (GH)
production, due, in the vast majority of cases, to the presence of a GH-secreting pituitary …

The mechanisms accounting for the functional changes of α-and β-cells over the course of
type 1 diabetes (T1D) development are largely unknown. Permitted by our established …

Transcription factors (TFs) are indispensable for maintaining cell identity through regulating
cell-specific gene expression. Distinct cell identities derived from a common progenitor are …

Pancreatic alpha cell activity and glucagon secretion lower as glucose levels increase.
While part of the decrease is regulated by glucose itself, paracrine signaling by their …

Background Alternative and complementary therapies play an imperative role in the clinical
management of Type 2 diabetes mellitus (T2DM), and exploring and utilizing natural …

In humans, type 2 diabetes mellitus shows a higher prevalence in men compared with
women, a phenotype that has been attributed to a lower peripheral insulin sensitivity in men …

Introduction Spatial biology is an emerging interdisciplinary field facilitating biological
discoveries through the use of spatial omics technologies. Recent advancements in spatial …