p63: a crucial player in epithelial stemness regulation
Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …
Myoepithelial cells: their origin and function in lacrimal gland morphogenesis, homeostasis, and repair
HP Makarenkova, DA Dartt - Current molecular biology reports, 2015 - Springer
Lacrimal gland (LG) is an exocrine tubuloacinar gland that secretes the aqueous layer of the
tear film. LG epithelium is composed of ductal, acinar, and myoepithelial cells (MECs) …
tear film. LG epithelium is composed of ductal, acinar, and myoepithelial cells (MECs) …
In vitro and in vivo development of the human airway at single-cell resolution
AJ Miller, Q Yu, M Czerwinski, YH Tsai, RF Conway… - Developmental cell, 2020 - cell.com
Bud tip progenitor cells give rise to all murine lung epithelial lineages and have been
described in the developing human lung; however, the mechanisms controlling human bud …
described in the developing human lung; however, the mechanisms controlling human bud …
Rapid expansion of human epithelial stem cells suitable for airway tissue engineering
Rationale: Stem cell–based tracheal replacement represents an emerging therapeutic
option for patients with otherwise untreatable airway diseases including long-segment …
option for patients with otherwise untreatable airway diseases including long-segment …
p73 is required for multiciliogenesis and regulates the Foxj1-associated gene network
CB Marshall, DJ Mays, JS Beeler, JM Rosenbluth… - Cell reports, 2016 - cell.com
We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC
differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of …
differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of …
A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of development
The specialized cell types of the mucociliary epithelium (MCE) lining the respiratory tract
enable continuous airway clearing, with its defects leading to chronic respiratory diseases …
enable continuous airway clearing, with its defects leading to chronic respiratory diseases …
Low‐level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair
Low‐level laser therapy (LLLT) has been extensively employed to improve epithelial wound
healing, though the exact response of epithelium maturation and stratification after LLLT is …
healing, though the exact response of epithelium maturation and stratification after LLLT is …
ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer
Distinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell
carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation …
carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation …
[HTML][HTML] Toxicological assessment of E-cigarette flavored E-liquids aerosols using Calu-3 cells: A 3D lung model approach
Scientific progress and ethical considerations are increasingly shifting the toxicological
focus from in vivo animal models to in vitro studies utilizing physiologically relevant cell …
focus from in vivo animal models to in vitro studies utilizing physiologically relevant cell …
ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia
M Haas, JLG Vázquez, DI Sun, HT Tran, M Brislinger… - Cell reports, 2019 - cell.com
Mucociliary epithelia provide a first line of defense against pathogens. Impaired
regeneration and remodeling of mucociliary epithelia are associated with dysregulated …
regeneration and remodeling of mucociliary epithelia are associated with dysregulated …