Nuclear copies of mitochondrial DNA (mtDNA) have contaminated PCR-based
mitochondrial studies of over 64 different animal species. Since the last review of these …

Since the introduction of the first commercial capillary electrophoresis (CE) instrument a
decade ago, CE applications have become widespread. Today, CE is a versatile analytical …

One of the most important breakthroughs in the history of genetics was the discovery that
mutations can be induced (Muller, 1930; Stadler, 1932). The high frequency with which …

With the accumulation of large-scale sequence data, emphasis in genomics has shifted from
determining gene structure to testing gene function, and this relies on reverse genetic …

Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues
as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant …

The invention relates to a method for identifying inherited point mutations in a targeted
region of the genome in a large population of individuals and determining which inherited …

Analytical Chemistry has changed its policy on its biannual reviews. Rather than providing
an encyclopedic listing of papers in a specific topic, authors are asked to focus their reviews …

With the completion of rice genome sequencing, large collection of expression data and the
great efforts in annotating rice genomes, the next challenge is to systematically assign …

Early molecular methods in clinical genetic diagnostics were frequently regarded as
unambiguous and definitive. The power of modern molecular biology was seen as sufficient …

Point and deletion mutations and a general depletion of mammalian mitochondrial DNA
(mtDNA) give rise to a wide variety of medical syndromes that are refractory to treatment …