The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …

The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …

In Darwin's and Mendel's times, researchers investigated a wealth of organisms, chosen to
solve particular problems for which they seemed especially well suited. Later, a focus on a …

Molecular genetics approaches in zebrafish research are hampered by the lack of a
ubiquitous transgene driver element that is active at all developmental stages. Here, we …

Background How different immune cell compartments contribute to a successful immune
response is central to fully understanding the mechanisms behind normal processes such …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

Targeted gene expression is a powerful approach to study the function of genes and cells in
vivo. In Drosophila, the P element-mediated Gal4-UAS method has been successfully used …

The Tol2 element is a naturally occurring active transposable element found in vertebrate
genomes. The Tol2 transposon system has been shown to be active from fish to mammals …

Abstract Neurons using serotonin (5-HT) as neurotransmitter and/or modulator have been
identified in the central nervous system in representatives from all vertebrate clades …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …