One of the most exciting new therapies for cancer involves the use of autologous T cells that
are engineered to recognize and destroy cancerous cells. Patients with previously …

Fibrosis results from aberrant wound healing and is characterized by an accumulation of
extracellular matrix, impairing the function of an affected organ. Increased deposition of …

Background & Aims Fibroblast activation protein (FAP) is expressed on activated fibroblast.
Its role in fibrosis and desmoplasia is controversial, and data on pharmacological FAP …

Purpose This study aimed to compare the detection performance of [68 Ga] Ga-DOTA-FAPI-
04 and [18F] FDG PET/CT in the patients with various oncological and non-oncological …

Rationale: Sustained activation of lung fibroblasts and the resulting oversynthesis of the
extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs) …

To date, pulmonary fibrosis remains an unmet medical need. In this study, we evaluated the
potency of mesenchymal stromal cell (MSC) secretome components to prevent pulmonary …

Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …

The development of tissue fibrosis is a complex process involving the interaction of multiple
cell types, which makes the search for antifibrotic agents rather challenging. So far …

BACKGROUND: Myofibroblasts are primary cells involved in chronic response-induced
cardiac fibrosis. Fibroblast activation protein (FAP) is a relatively specific marker of activated …

Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often
resulting in fibrostenosis and bowel obstruction, necessitating surgical intervention with high …