Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy
compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Following estrogenic activation, the estrogen receptor-α (ERα) directly regulates the
transcription of target genes via DNA binding. MicroRNAs (miRNAs) modulated by ERα …

Humans differ from other primates by marked differences in cognitive abilities and a
significantly larger brain. These differences correlate with metabolic changes, as evidenced …

We report the latest structural information on PREP1 tumor suppressor, the specific
“oncogene” and “tumor suppressive” signatures of MEIS1 and PREP1, the molecular rules …

Introduction Bone is the most common site of breast cancer metastasis, and complications
associated with bone metastases can lead to a significantly decreased patient quality of life …

The adult frog retina retains a reservoir of active neural stem cells that contribute to
continuous eye growth throughout life. We found that Yap, a downstream effector of the …

Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral
integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse …

Aging exacerbates neointimal formation by reducing apoptosis of vascular smooth muscle
cells (VSMCs) and induces inflammation within vascular wall. Prep1 is a homeodomain …

Disruption of mouse Prep1, which codes for a homeodomain transcription factor, leads to
embryonic lethality during post-implantation stages. Prep1–/–embryos stop developing after …