Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although
there are multiple paths by which hippocampal deterioration occurs in late life, the authors …

We have recently shown that a single bout of acute cardiovascular exercise improves motor
skill learning through an optimization of long-term motor memory. Here we expand this …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative …

BDNF/TrkB neurotrophic signaling regulates neuronal development, differentiation, and
survival, and deficient BDNF/TrkB activity underlies neurodegeneration in Alzheimer's …

The current study examined how a randomized one-year aerobic exercise program for
healthy older adults would affect serum levels of brain-derived neurotrophic factor (BDNF) …

Background: The cAMP signaling pathway, and its downstream neurotrophic factor BDNF,
are major targets of antidepressant medications. Abnormalities in this pathway have …

Emerging evidence indicates that moderate intensity aerobic exercise is positively
correlated with cognitive function and memory. However, the exact mechanisms underlying …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …