Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …

The dynamic coordination of processes controlling the quality of the mitochondrial network is
crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

Post-translational modifications of proteins control many biological processes, and
examining their diversity is critical for understanding mechanisms of cell regulation. Mass …

Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of
mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes …

Among the complex determinants of aging, mitochondrial dysfunction has been in the
spotlight for a long time. As the hub for many cellular functions, the maintenance of an …

Background The maintenance of cell metabolism and homeostasis is a fundamental
characteristic of living organisms. In eukaryotes, mitochondria are the cornerstone of these …

A decline in mitochondrial activity has been associated with aging and is a hallmark of many
neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and …

Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many
patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 …