Synergistic enhancement of cancer therapy using HDAC inhibitors: opportunity for clinical trials
L Hontecillas-Prieto, R Flores-Campos, A Silver… - Frontiers in …, 2020 - frontiersin.org
Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …
SCF ubiquitin ligase-targeted therapies
The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted
the therapeutic potential of targeting this protein degradation system. However, proteasome …
the therapeutic potential of targeting this protein degradation system. However, proteasome …
Protein neddylation and its alterations in human cancers for targeted therapy
L Zhou, W Zhang, Y Sun, L Jia - Cellular signalling, 2018 - Elsevier
Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
E1 enzymes as therapeutic targets in cancer
Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy
Significance: Protein neddylation is catalyzed by an E1 NEDD8-activating enzyme (NAE), an
E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates …
E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates …
Phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with advanced solid tumors
J Sarantopoulos, GI Shapiro, RB Cohen, JW Clark… - Clinical Cancer …, 2016 - AACR
Purpose: To determine the dose-limiting toxicities (DLTs) and maximum tolerated dose
(MTD) of the investigational NEDD8-activating enzyme (NAE) inhibitor pevonedistat (TAK …
(MTD) of the investigational NEDD8-activating enzyme (NAE) inhibitor pevonedistat (TAK …
Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
DJ Fu, T Wang - Journal of Hematology & Oncology, 2023 - Springer
NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …
Overactivated neddylation pathway as a therapeutic target in lung cancer
Background A number of oncoproteins and tumor suppressors are known to be neddylated,
but whether the neddylation pathway is entirely activated in human cancer remains …
but whether the neddylation pathway is entirely activated in human cancer remains …
An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma
DS Shulman, SB Whittle, D Surdez, KM Bailey… - NPJ precision …, 2022 - nature.com
The advent of dose intensified interval compressed therapy has improved event-free survival
for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a …
for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a …
Protein neddylation and its role in health and diseases
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …