Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Health emerges from coordinated psychobiological processes powered by mitochondrial
energy transformation. But how do mitochondria regulate the multisystem responses that …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …

Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …

Aging is a process of progressive change. To develop biological models of aging,
longitudinal datasets with high temporal resolution are needed. Here we report a multi …

Mitochondrial diseases are a heterogeneous group of monogenic disorders that result from
impaired oxidative phosphorylation (OXPHOS). As neuromuscular tissues are highly energy …

The mitochondrion is a major hub of cellular metabolism and involved directly or indirectly in
almost all biological processes of the cell. In mitochondrial diseases, compromised …

Telomere attrition is a hallmark of biological aging, contributing to cellular replicative
senescence. However, few studies have examined the determinants of telomere attrition in …

The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by
recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses …