Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Mechanotransduction research has focused historically on how externally applied forces
can affect cell signalling and function. A growing body of evidence suggests that contractile …

Cardiac fibrosis is a substantial problem in managing multiple forms of heart disease.
Fibrosis results from an unrestrained tissue repair process orchestrated predominantly by …

The molecular regulation of smooth muscle cell (SMC) behavior is reviewed, with particular
emphasis on stimuli that promote the contractile phenotype. SMCs can shift reversibly along …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

Serum response factor (SRF) is a highly conserved and widely expressed, single copy
transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis …

Rho GTPases control cytoskeletal dynamics through cytoplasmic effectors and regulate
transcriptional activation through myocardin-related transcription factors (MRTFs), which are …

Significance: Myofibroblasts are responsible for wound closure that occurs in healed acute
wounds. However, their actions can result in disfiguring scar contractures, compromised …

The association of transcriptional coactivators with sequence-specific DNA-binding proteins
provides versatility and specificity to gene regulation and expands the regulatory potential of …