Small heterocycles in multicomponent reactions

BH Rotstein, S Zaretsky, V Rai, AK Yudin - Chemical reviews, 2014 - ACS Publications
Small-ring heterocycles have found many applications both as useful starting materials in
the synthesis of more elaborate structures and as valuable targets of synthesis. Our review …

Palladium‐catalyzed cross‐coupling reactions in total synthesis

KC Nicolaou, PG Bulger… - Angewandte Chemie …, 2005 - Wiley Online Library
In studying the evolution of organic chemistry and grasping its essence, one comes quickly
to the conclusion that no other type of reaction plays as large a role in shaping this domain …

[图书][B] Transition metals for organic synthesis

C Bolm, M Beller - 2004 - sutlib2.sut.ac.th
for Organic Synthesis Page 1 Edited by Matthias Bellerand Carsten Bolm WILEY-VCH Transition
Metals for Organic Synthesis Building Blocks and Fine Chemicals Volume 2 Second Revised …

Immunopharmacology of rapamycin

RT Abraham, GJ Wiederrecht - Annual review of immunology, 1996 - annualreviews.org
▪ Abstract The potent immunosuppressive drugs FK506 and rapamycin interfere with signal
transduction pathways required for T cell activation and growth. The distinct inhibitory effects …

Palladiumkatalysierte kreuzkupplungen in der totalsynthese

KC Nicolaou, PG Bulger, D Sarlah - Angewandte Chemie, 2005 - Wiley Online Library
Wenn man die Entwicklung der organischen Chemie betrachtet, kommt man schnell zu dem
Schluss, dass kein Reaktionstyp dieses Gebiet in vergleichbarer Weise geprägt hat wie die …

Small molecule natural products in the discovery of therapeutic agents: the synthesis connection

RM Wilson, SJ Danishefsky - The Journal of organic chemistry, 2006 - ACS Publications
Natural products have been a rich source of agents of value in medicine. They have also
inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import …

Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance

KC Nicolaou, CRH Hale, C Nilewski… - Chemical Society …, 2012 - pubs.rsc.org
The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …

Desulfonylation reactions: Recent developments

C Nájera, M Yus - Tetrahedron, 1999 - Elsevier
1. Introduction 2. Reductive Desulfonylation 2.1. Replacement of the sulfone group by
hydrogen 2.1. 1. Alkyl sulfones 2.1. la ct-Functionalised alkyl sulfones 2.1. 1. b. Other …

The role of 1, 3-dithianes in natural product synthesis

M Yus, C Nájera, F Foubelo - Tetrahedron, 2003 - Elsevier
The normal reactivity of a carbonyl compound (I) is as an a 1-reagent (II) and the temporary
reversal of the characteristic pattern of reactivity of a functional group is described by the …

Prins‐Type Macrocyclizations as an Efficient Ring‐Closing Strategy in Natural Product Synthesis

EA Crane, KA Scheidt - Angewandte Chemie International …, 2010 - Wiley Online Library
Prins‐type macrocyclizations have recently emerged as a successful strategy in the
synthesis of polyketide‐derived natural products. This reaction provides a concise and …