Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

Ubiquitin and ubiquitin-like proteins typically use distinct machineries to facilitate diverse
functions. The immunosuppressive ubiquitin-like protein Fubi is synthesized as an N …

Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies …

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin
moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in …

Cys‐tematic modification: Cysteine is a versatile amino acid for selective chemical
modification of proteins. Both chemical and biological innovations made possible by …

Abstract Purpose: Bortezomib (Velcade), a dipeptide boronate 20S proteasome inhibitor and
an approved treatment option for multiple myeloma, is associated with a treatment …

The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for
cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical …

Molecules that covalently bind macromolecular targets have found widespread applications
as activity-based probes and as irreversibly binding drugs. However, the general reactivity of …

Genome sequencing projects have ushered biological research into a new age where
scientists are confronted with the daunting undertaking of assigning functions to the full …