Background Total neoadjuvant therapy (TNT) is a novel approach for locally advanced rectal
cancer (LARC), which attempts to deliver both systemic chemotherapy and neoadjuvant …

ASCO Guidelines provide recommendations with comprehensive review and analyses of
the relevant literature for each recommendation, following the guideline development …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

Importance Total neoadjuvant therapy has been increasingly adopted for multimodal rectal
cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy …

PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is
not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally …

The determination of an optimal treatment plan for an individual patient with rectal cancer is
a complex process. In addition to decisions relating to the intent of rectal cancer surgery (ie …

Importance Treatment of locally advanced rectal cancer (LARC) involves neoadjuvant
chemoradiotherapy plus total mesorectal excision and adjuvant chemotherapy. However …

Colorectal cancer (CRC) is a major contributor to cancer-associated morbidity worldwide
and over one-third of CRC is located in the rectum. Neoadjuvant chemoradiotherapy (nCRT) …

Background and purpose The RAPIDO trial demonstrated a decrease in disease-related
treatment failure (DrTF) and an increase in pathological complete responses (pCR) in locally …

A few months ago, results from two randomised phase III trials of total neoadjuvant therapy
(TNT) in locally advanced rectal cancer were presented (RAPIDO and PRODIGE 23) …