Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

Rearranged during transfection (RET) is involved in the physiological development of some
organ systems. Activating RET alterations via either gene fusions or point mutations are …

Activating receptor tyrosine kinase RET (rarranged during transfection) gene alterations
have been identified as oncogenic in multiple malignancies. RET gene rearrangements …

The RET receptor tyrosine kinase is crucial for normal development but also contributes to
pathologies that reflect both the loss and the gain of RET function. Activation of RET occurs …

The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …

Rearranged during transfection (RET) receptor tyrosine kinase was first identified over thirty
years ago as a novel transforming gene. Since its discovery and subsequent pathway …

Src family tyrosine kinases (SFKs) are involved in a diverse array of physiological
processes, as highlighted in this review. An overview of how SFKs interact with, and …

The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived
cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration …

In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and
activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show …