Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin
resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of …

In patients with diabetes, nerve injury is a common complication that leads to chronic pain,
numbness and substantial loss of quality of life. Good glycemic control can decrease the …

Depression and type 2 diabetes (T2D) are highly comorbid disorders that carry a large
public health burden. However, there is a clear lack of knowledge of the neural pathological …

While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not
been demonstrated directly in that disorder. We provide such a demonstration here by …

Background Chronic high-fat diet (HFD) consumption caused not only obese-insulin
resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by …

Abstract Dipeptidyl peptidase-4 inhibitor (vildagliptin) has been shown to exert beneficial
effects on insulin sensitivity and neuroprotection in obese-insulin resistance. Recent studies …

Alzheimer's disease (AD) is the 3rd most costly disease and the leading cause of dementia.
It can linger for many years, but ultimately is fatal, the 6th leading cause of death …

Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

It is widely recognized that obesity and associated metabolic changes are considered a risk
factor to age-associated cognitive decline. Inflammation and increased oxidative stress in …

Estrogen affects proliferation and migration of different skin components, thus influencing
wound healing processes. The human keratinocyte cell line NCTC 2544 has been used to …