Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Fibrosis–a debilitating condition that can occur in most organs–is characterized by excess
deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of …

Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a
variety of organs, including the lungs. However, the causal role of reactive oxygen species …

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …

Mitochondria are critically involved in reactive oxygen species (ROS)-dependent lung
diseases, such as lung fibrosis, asbestos, chronic airway diseases and lung cancer …

Diabetic wounds are recalcitrant to healing. However, the mechanism causing this
dysfunction is not fully understood. High expression of matrix metalloproteinase-9 (MMP-9) …

Asbestos causes asbestosis and malignancies by molecular mechanisms that are not fully
understood. The modes of action underlying asbestosis, lung cancer, and mesothelioma …

Idiopathic pulmonary fibrosis (IPF) is a debilitating condition where excess collagen
deposition occurs in the extracellular matrix. At first sight, it is expected that the level of …

Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely
understood. Emerging evidence suggests changes in mitochondrial quality control are a …

The tumor suppressor protein p53 is an important transcriptional factor for multiple proteins
involved in the cellular DNA damage response, and it is likely important in inflammation …