[PDF][PDF] Bioanalytical method validation and its pharmaceutical application-a review

LV Sonawane, BN Poul, SV Usnale… - Pharm Anal …, 2014 - mcpnilanga.org
Bioanalytical methods, based on a variety of physico-chemical and biological techniques
such as chromatography, immunoassay and mass spectrometry, must be validated prior to …

Synthetic peptides in doping control: a powerful tool for an analytical challenge

NA Gómez-Guerrero, NM González-López… - ACS …, 2022 - ACS Publications
Peptides are very diverse molecules that can participate in a wide variety of biological
processes. In this way, peptides are attractive for doping, since these molecules can activate …

Simplifying and expanding analytical capabilities for various classes of doping agents by means of direct urine injection high performance liquid chromatography high …

C Görgens, S Guddat, A Thomas, P Wachsmuth… - … of Pharmaceutical and …, 2016 - Elsevier
So far, in sports drug testing compounds of different classes are processed and measured
using different screening procedures. The constantly increasing number of samples in …

Simplifying and expanding the screening for peptides< 2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry

A Thomas, C Görgens, S Guddat… - Journal of separation …, 2016 - Wiley Online Library
The analysis of low‐molecular‐mass peptides in doping controls has become a mandatory
aspect in sports drug testing and, thus, the number of samples that has to be tested for these …

Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls

M Thevis, W Schänzer - Journal of pharmaceutical and biomedical analysis, 2014 - Elsevier
The number and diversity of potentially performance-enhancing substances is continuously
growing, fueled by new pharmaceutical developments but also by the inventiveness and, at …

Large-molecule quantification: sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF

LP Morin, JN Mess, F Garofolo - Bioanalysis, 2013 - Taylor & Francis
Background: Bioanalysts are continuously looking for innovative ideas or instruments to
increase the sensitivity and selectivity of their assays. Research for better mass …

Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass …

A Thomas, K Walpurgis, O Krug, W Schänzer… - … of Chromatography A, 2012 - Elsevier
In the present study, a screening assay was developed comprising 11 prohibited peptides (<
1.5 kDa) that are sufficiently purified from urine using weak cation exchange with …

Application and challenges in using LC–MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery

J Zheng, J Mehl, Y Zhu, B Xin, T Olah - Bioanalysis, 2014 - Taylor & Francis
As more protein therapeutics enter the drug-discovery pipeline, the traditional ligand-binding
assay (LBA) faces additional challenges to meet the rapid and diverse bioanalytical needs …

Current trends in mass spectrometry of peptides and proteins: application to veterinary and sports‐doping control

I van den Broek, M Blokland… - Mass spectrometry …, 2015 - Wiley Online Library
Detection of misuse of peptides and proteins as growth promoters is a major issue for sport
and food regulatory agencies. The limitations of current analytical detection strategies for …

Metabolism of growth hormone releasing peptides

A Thomas, P Delahaut, O Krug, W Schänzer… - Analytical …, 2012 - ACS Publications
New, potentially performance enhancing compounds have frequently been introduced to licit
and illicit markets and rapidly distributed via worldwide operating Internet platforms …