The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies
of healing. Here, we investigate the cellular interactions between innate immune cells and …

During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

The brain vasculature has been increasingly recognized as a key player that directs brain
development, regulates homeostasis, and contributes to pathological processes. Following …

Capillary networks are essential for distribution of blood flow through the brain, and
numerous other homeostatic functions, including neurovascular signal conduction and …

Mural cells (MCs) consisting of vascular smooth muscle cells and pericytes cover the
endothelial cells (ECs) to regulate vascular stability and homeostasis. Here, we clarified the …

Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective
circulation to compromised tissues in patients. Deciphering the origin and specification of …

Despite the critical role of endothelial Wnt/β-catenin signaling during central nervous system
(CNS) vascularization, how endothelial cells sense and respond to specific Wnt ligands and …

Tissue vascularization entails the formation of a blood vessel plexus, which remodels into
arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration …