Redesigning enzymes for biocatalysis: exploiting structural understanding for improved selectivity
Y Ding, G Perez-Ortiz, J Peate… - Frontiers in Molecular …, 2022 - frontiersin.org
The discovery of new enzymes, alongside the push to make chemical processes more
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …
sustainable, has resulted in increased industrial interest in the use of biocatalytic processes …
Inverting the enantiopreference of nitrilase‐catalyzed desymmetric hydrolysis of prochiral dinitriles by reshaping the binding pocket with a mirror‐image strategy
S Yu, J Li, P Yao, J Feng, Y Cui, J Li… - Angewandte Chemie …, 2021 - Wiley Online Library
A mirror‐image strategy, that is, symmetry analysis of the substrate‐binding pocket, was
applied to identify two key amino acid residues W170 and V198 that possibly modulate the …
applied to identify two key amino acid residues W170 and V198 that possibly modulate the …
The Role of Substrate-Coenzyme Crosstalk in Determining Turnover Rates in Rhodococcus ruber Alcohol Dehydrogenase
TR Enugala, MC Morató, SCL Kamerlin… - ACS …, 2020 - ACS Publications
Eight related alcohol dehydrogenases, which had been originally isolated by laboratory
evolution of ADH-A from Rhodococcus ruber DSM44541 for modified substrate scopes …
evolution of ADH-A from Rhodococcus ruber DSM44541 for modified substrate scopes …
Engineered P450 BM3 and cpADH5 coupled cascade reaction for β-oxo fatty acid methyl ester production in whole cells
Y Ensari, G de Almeida Santos, AJ Ruff… - Enzyme and Microbial …, 2020 - Elsevier
Hydroxy-or ketone-functionalized fatty acid methyl esters (FAMEs) are important compounds
for production of pharmaceuticals, vitamins, cosmetics or dietary supplements. Biocatalysis …
for production of pharmaceuticals, vitamins, cosmetics or dietary supplements. Biocatalysis …
Reversal of Regioselectivity in Zinc‐Dependent Medium‐Chain Alcohol Dehydrogenase from Rhodococcus erythropolis toward Octanone Derivatives
The zinc‐dependent medium‐chain alcohol dehydrogenase from Rhodococcus erythropolis
(ReADH) is one of the most versatile biocatalysts for the stereoselective reduction of ketones …
(ReADH) is one of the most versatile biocatalysts for the stereoselective reduction of ketones …
[PDF][PDF] Synthesis of oxo-fatty acid esters in a whole cell cascade reaction with engineered monooxygenase (P450 BM3) and dehydrogenase (cpADH5) variants
Y Ensari - 2018 - d-nb.info
Hydroxyl or ketone functionalized fatty acid methyl esters are important compounds for
production of pharmaceuticals, cosmetics or dietary supplements. For instance, 3 …
production of pharmaceuticals, cosmetics or dietary supplements. For instance, 3 …