Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most
abundant non-collagenous protein expressed in mineralized tissues. This review will focus …

Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …

Osteogenesis Imperfecta (OI) comprises a heterogeneous group of patients who share bone
fragility and deformities as the main characteristics, albeit with different degrees of severity …

Bone material strength is determined by several factors, such as bone mass, matrix
composition, mineralization, architecture and shape. From a clinical perspective, bone …

Osteogenesis imperfecta (OI) is a rare congenital disease with a wide spectrum of severity
characterized by skeletal deformity and increased bone fragility as well as additional …

Osteogenesis imperfecta, or brittle bone disease, is a congenital disease that primarily
causes low bone mass and bone fractures but it can negatively affect other organs. It is …

Osteogenesis imperfecta (OI) is a collagen-related bone dysplasia. We identified an X-linked
recessive form of OI caused by defects in MBTPS2, which encodes site-2 metalloprotease …

Ehlers–Danlos syndrome (EDS) describes a group of clinical entities in which the
connective tissue, primarily that of the skin, joint and vessels, is abnormal, although the …

Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …