Protein-protein interactions (PPIs) are fundamental to cellular signaling and transduction
which marks them as attractive therapeutic drug development targets. What were once …

There are promising new therapeutic agents for CRC patients, including novel small-
molecule inhibitors and immune checkpoint blockers. We focused on emerging CRC's …

A novel probiotics-derived protein, P8, suppresses the growth of colorectal cancer (CRC).
P8 can penetrate the cell membrane via endocytosis and cause cell cycle arrest in DLD-1 …

Purpose The blood-brain barrier can prevent circulating tumor DNA (ctDNA) derived from
the central nervous system from entering the blood making it challenging to evaluate …

The application of machine learning techniques in biological research, especially when
dealing with limited data availability, poses significant challenges. In this study, we …

Protein–protein interactions regulate many essential enzymatic processes in the cell.
Somatic mutations outside of an enzyme active site can therefore impact cellular function by …

BACKGROUND: Gastric cancer (GC) is the third leading cause of cancer worldwide.
According to the Lauren classification, gastric adenocarcinoma is divided into two subtypes …

Recognition of short linear motifs (SLiMs) or peptides by proteins is an important component
of many cellular processes. However, due to limited and degenerate binding motifs …

Abstract CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) is one of the
hallmark of biological tools, contemplated as a valid and hopeful alternatives to genome …

Many biological functions are mediated by protein–protein interactions (PPIs), often
involving specific structural modules, such as SH2 domains. Inhibition of PPIs is a …