Clinical prospect of mesenchymal stromal/stem cell-derived extracellular vesicles in kidney disease: Challenges and the way forward

M Kosanović, B Milutinović, TJ Kutzner, Y Mouloud… - Pharmaceutics, 2023 - mdpi.com
Kidney disease is a growing public health problem worldwide, including both acute and
chronic forms. Existing therapies for kidney disease target various pathogenic mechanisms; …

Regulated necrosis role in inflammation and repair in acute kidney injury

J Guerrero-Mauvecin, N Villar-Gómez… - Frontiers in …, 2023 - frontiersin.org
Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …

[HTML][HTML] Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

A Al-Jipouri, À Eritja, M Bozic - International Journal of Molecular …, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanoparticles released from various cell types that have
emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in …

Naïve or engineered extracellular vesicles from different cell sources: therapeutic tools for kidney diseases

E Ceccotti, G Saccu, MB Herrera Sanchez, S Bruno - Pharmaceutics, 2023 - mdpi.com
Renal pathophysiology is a multifactorial process involving different kidney structures. Acute
kidney injury (AKI) is a clinical condition characterized by tubular necrosis and glomerular …

Extracellular vesicles from induced pluripotent stem cell-derived mesenchymal stem cells enhance the recovery of acute kidney injury

S Hong, H Kim, J Kim, S Kim, TS Park, TM Kim - Cytotherapy, 2024 - Elsevier
Background aims To investigate whether the extracellular vesicles (EVs) from mesenchymal
stem cell–like cells derived from induced pluripotent stem cells (iMSC-EVs) can inhibit the …

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

RJ Miron, NE Estrin, A Sculean… - Periodontology 2000, 2024 - Wiley Online Library
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells
with the ability to communicate with other tissues and cell types over long distances. Their …

Current advances in nanomedicine-based therapies for acute kidney injury

R Chang, X Qu, Y Ye, Y Qu, B Chu, Z Qian - Chinese Chemical Letters, 2024 - Elsevier
Acute kidney injury (AKI) is a prevalent clinical syndrome characterized by a rapid loss of
renal filtration function, with high incidence and mortality rates that are steadily rising. AKI …

Unveiling the Role of Exosomes in the Pathophysiology of Sepsis: Insights into Organ Dysfunction and Potential Biomarkers

GM Gebeyehu, S Rashidiani, B Farkas… - International Journal of …, 2024 - mdpi.com
Extracellular vesicles (EVs) are tools for intercellular communication, mediating molecular
transport processes. Emerging studies have revealed that EVs are significantly involved in …

[HTML][HTML] Extracellular Vesicles in Viral Liver Diseases

E Kouroumalis, I Tsomidis, A Voumvouraki - Viruses, 2024 - mdpi.com
Extracellular vesicles (EVs) are bilayer vesicles released by cells in the microenvironment of
the liver including parenchymal and non-parenchymal cells. They are the third important …

The Role of Extracellular Vesicles in Aging and Disease

C Borrás, C Mas-Bargues - International Journal of Molecular Sciences, 2023 - mdpi.com
Cells are exposed to various internal and external factors that can cause damage over time.
This damage can result from exposure to harmful chemicals, radiation, inflammation, genetic …