One is not enough: understanding and modeling polysubstance use

EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

New benzodiazepines for sedation

EM Cornett, MB Novitch, AJ Brunk, KS Davidson… - Best Practice & …, 2018 - Elsevier
There are currently new drugs being developed that have benzodiazepine properties. This
review will examine remimazolam, 3-hydroxyphenazapam, adinazolam, clonazolam, and …

Increasing presence of xylazine in heroin and/or fentanyl deaths, Philadelphia, Pennsylvania, 2010–2019

J Johnson, L Pizzicato, C Johnson… - Injury …, 2021 - injuryprevention.bmj.com
Reports from active drug users state that xylazine, the veterinary tranquilliser, has been
increasing in the illicit drug supply in Philadelphia. To describe trends and characteristics of …

Analysis of fentanyl and 18 novel fentanyl analogs and metabolites by LC–MS-MS, and report of fatalities associated with methoxyacetylfentanyl and …

MF Fogarty, DM Papsun… - Journal of analytical …, 2018 - academic.oup.com
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are
infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported …

Unintentional drug overdose: Is more frequent use of non-prescribed buprenorphine associated with lower risk of overdose?

RG Carlson, R Daniulaityte, SM Silverstein… - International Journal of …, 2020 - Elsevier
Background Unintentional drug overdoses have reached epidemic levels in the US This
study tests the hypothesis that people who have used non-prescribed buprenorphine more …

Prescription tranquilizer/sedative misuse prevalence and correlates across age cohorts in the US

TS Schepis, CJ Teter, L Simoni-Wastila, SE McCabe - Addictive Behaviors, 2018 - Elsevier
Background Prescription tranquilizer/sedative (eg, alprazolam, zolpidem) misuse (ie, use in
ways not intended by the prescriber or without a prescription) is understudied, with little …

Polydrug use patterns, risk behavior and unmet healthcare need in a community-based sample of women who use cocaine, heroin or methamphetamine

J Lorvick, EN Browne, BH Lambdin, M Comfort - Addictive behaviors, 2018 - Elsevier
Background The use of multiple illicit drugs (polydrug use) is associated with health-related
harms and elevated risk of drug overdose. Polydrug use in common among women who use …

Prescription fill patterns for benzodiazepine and opioid drugs during the COVID-19 pandemic in the United States

C de Dios, BS Fernandes, K Whalen… - Drug and alcohol …, 2021 - Elsevier
Background COVID-19 and resulting mitigation measures in the United States (US) brought
about limited access to medical care that has been linked to increases in mental health …

A comprehensive multivariate model of biopsychosocial factors associated with opioid misuse and use disorder in a 2017–2018 United States national survey

FA Montiel Ishino, PR McNab, T Gilreath, B Salmeron… - BMC public health, 2020 - Springer
Background Few studies have comprehensively and contextually examined the relationship
of variables associated with opioid use. Our purpose was to fill a critical gap in …

[HTML][HTML] Diazepam

JS Dhaliwal, A Rosani, A Saadabadi - 2019 - europepmc.org
Objectives: Identify the indications for using diazepam. Summarize the adverse effects of
diazepam. Review the mechanism of action of diazepam. Outline the importance of …