Gap junctions and connexin hemichannels mediate intercellular and extracellular
communication, respectively. While gap junctions are seen as the “good guys” by controlling …

Therapeutic hypothermia is now well established to significantly improve survival without
disability after neonatal encephalopathy (NE). To further improve outcomes, we need to …

Prickly Ash Seeds (PAS), as a traditional Chinese medicinal herb, have pharmacological
effects such as anti-asthma, anti-thrombotic, and anti-bacterial, but their impact on gut …

Pannexin channels play fundamental roles in regulating inflammation and have been
implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Therapeutic hypothermia is now proven to reduce death or disability in term and near‐term
born infants with moderate to severe hypoxic‐ischemic encephalopathy. Nevertheless …

(1) Background: In this study, we aimed to explore the regulatory mechanism of miR-124-3p
microglial exosomes, as they were previously reported to modulate neuroinflammation and …

Under nonpathological conditions, the extracellular nucleotide concentration remains
constant and low (nM range) because of a close balance between ATP release and ATP …

Increased Connexin43 hemichannel opening is associated with inflammasome pathway
activation and inflammation in a range of pathologies including ocular disorders, such as …

Background Tubulointerstitial fibrosis represents the key underlying pathology of Chronic
Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated …