Targeted imaging of bacterial infections: advances, hurdles and hopes

M van Oosten, M Hahn, LMA Crane… - FEMS microbiology …, 2015 - academic.oup.com
Bacterial infections represent an increasing problem in modern health care, in particular due
to ageing populations and accumulating bacterial resistance to antibiotics. Diagnosis is …

99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

SAR Naqvi - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Discovery of penicillin marked a turning point in the history of infection therapy which also
led to the emergence of bacterial resistance. It is now 100 years to fight with ever‐muted …

Ciprofloxacin: from infection therapy to molecular imaging

SAR Naqvi, S Roohi, A Iqbal, TA Sherazi… - Molecular biology …, 2018 - Springer
Diagnosis of deep-seated bacterial infection remains a serious medical challenge. The
situation is becoming more severe with the increasing prevalence of bacteria that are …

Gadolinium-labeled aminoglycoside and its potential application as a bacteria-targeting magnetic resonance imaging contrast agent

L Zhang, Y Liu, Q Zhang, T Li, M Yang, Q Yao… - Analytical …, 2018 - ACS Publications
Magnetic resonance imaging (MRI) is a powerful diagnostic technique that can penetrate
deep into tissue providing excellent spatial resolution without the need for ionizing radiation …

Synthesis, characterization and biological evaluation of 99mTc/Re–tricarbonyl quinolone complexes

TE Kydonaki, E Tsoukas, F Mendes… - Journal of Inorganic …, 2016 - Elsevier
New rhenium (I) tricarbonyl complexes with the quinolone antimicrobial agents oxolinic acid
(Hoxo) and enrofloxacin (Herx) and containing methanol, triphenylphosphine (PPh 3) or …

Fluoroquinolones as imaging agents for bacterial infection

SAR Naqvi, K Drlica - Dalton Transactions, 2017 - pubs.rsc.org
Diagnosis of deep-seated bacterial infection is difficult, as neither standard anatomical
imaging nor radiolabeled, autologous leukocytes distinguish sterile inflammation from …

Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation

H Eggleston, P Panizzi - Informatics, 2014 - mdpi.com
Molecular imaging by definition is the visualization of molecular and cellular processes
within a given system. The modalities and reagents described here represent a diverse …

Design of 5-fluorouracil (5-FU) loaded, folate conjugated peptide linked nanoparticles, a potential new drug carrier for selective targeting of tumor cells

J Kazi, R Mukhopadhyay, R Sen, T Jha, S Ganguly… - …, 2019 - pubs.rsc.org
In the present investigation folate peptide (FA-Pep) conjugated 5-fluorouracil (5-FU) loaded
nanoparticles were synthesized and their tumor targeting potentiality was monitored by …

Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inflammation and infection

T Kniess, M Laube, F Wüst, J Pietzsch - Dalton transactions, 2017 - pubs.rsc.org
In nuclear medicine, the detection of inflamed and infected lesions is of growing interest.
Extensive efforts have been made to develop radiopharmaceuticals specific for inflammation …

Structural characterization and pharmacological assessment in vitro/in vivo of a new copper(ii)-based derivative of enrofloxacin

RF Guo, HT Yan, RX Liu, HC Li, YC Liu, ZF Chen… - Metallomics, 2020 - academic.oup.com
Enrofloxacin (EFX) was selected as the medicinal ligand to afford a new copper (ii)-based
complex, EFX-Cu, which was structurally characterized by spectroscopic analyses including …