Methyltransferases: functions and applications

E Abdelraheem, B Thair, RF Varela… - …, 2022 - Wiley Online Library
In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives

S Tordjman, I Najjar, E Bellissant… - International journal of …, 2013 - mdpi.com
Abnormalities in melatonin physiology may be involved or closely linked to the
pathophysiology and behavioral expression of autistic disorder, given its role in …

Structure-guided isoform identification for the human transcriptome

MJ Sommer, S Cha, A Varabyou, N Rincon, S Park… - Elife, 2022 - elifesciences.org
Recently developed methods to predict three-dimensional protein structure with high
accuracy have opened new avenues for genome and proteome research. We explore a new …

Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders

C Pagan, H Goubran-Botros, R Delorme, M Benabou… - Scientific reports, 2017 - nature.com
Autism spectrum disorders (ASD) are characterized by a wide genetic and clinical
heterogeneity. However, some biochemical impairments, including decreased melatonin …

Pan‐Cancer analyses reveal Genomics and clinical characteristics of the Melatonergic regulators in cancer

J Zhang, H Jiang, K Du, T Xie, B Wang… - Journal of pineal …, 2021 - Wiley Online Library
Melatonin, an endogenous hormone, plays protective roles in cancer. In addition to
regulating circadian rhythms, sleep, and neuroendocrine activity, melatonin functions in …

Melatonin synthesis genes N‐acetylserotonin methyltransferases evolved into caffeic acid O‐methyltransferases and both assisted in plant terrestrialization

D Zhao, Z Yao, J Zhang, R Zhang, Z Mou… - Journal of pineal …, 2021 - Wiley Online Library
Terrestrialization is one of the most momentous events in the history of plant life, which leads
to the subsequent evolution of plant diversity. The transition species, in this process, had to …

Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay

OJ Veatch, JS Pendergast, MJ Allen, RM Leu… - Journal of autism and …, 2015 - Springer
Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes
whose products regulate endogenous melatonin modify sleep patterns and have been …

Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo

D Xu, H Lin, Y Tang, L Huang, J Xu, S Nian… - Horticulture …, 2021 - academic.oup.com
Corydalis yanhusuo WT Wang is a classic herb that is frequently used in traditional Chinese
medicine and is efficacious in promoting blood circulation, enhancing energy, and relieving …

Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine

P Daniel-Ivad, KS Ryan - Journal of Biological Chemistry, 2024 - ASBMB
Bisindoles are biologically active natural products that arise from the oxidative dimerization
of two molecules of l-tryptophan. In bacterial bisindole pathways, a core set of …

Walnut N-Acetylserotonin Methyltransferase Gene Family Genome-Wide Identification and Diverse Functions Characterization During Flower Bud Development

K Ma, R Xu, Y Zhao, L Han, Y Xu, L Li… - Frontiers in plant …, 2022 - frontiersin.org
Melatonin widely mediates multiple developmental dynamics in plants as a vital growth
stimulator, stress protector, and developmental regulator. N-acetylserotonin …