Network propagation: a universal amplifier of genetic associations
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
that drive disease. Fundamental to network analysis is the concept that genes underlying the …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Predicting HLA class II antigen presentation through integrated deep learning
Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules would be valuable for vaccine development and cancer immunotherapies …
molecules would be valuable for vaccine development and cancer immunotherapies …
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
Abstract ToppGene Suite (http://toppgene. cchmc. org; this web site is free and open to all
users and does not require a login to access) is a one-stop portal for (i) gene list functional …
users and does not require a login to access) is a one-stop portal for (i) gene list functional …
Leaders in Social Networks, the Delicious Case
Finding pertinent information is not limited to search engines. Online communities can
amplify the influence of a small number of power users for the benefit of all other users …
amplify the influence of a small number of power users for the benefit of all other users …
Prioritizing candidate disease genes by network-based boosting of genome-wide association data
Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …
genes based on the observation that similar mutational phenotypes arise from functionally …
Network analyses in systems pharmacology
SI Berger, R Iyengar - Bioinformatics, 2009 - academic.oup.com
Abstract Systems pharmacology is an emerging area of pharmacology which utilizes
network analysis of drug action as one of its approaches. By considering drug actions and …
network analysis of drug action as one of its approaches. By considering drug actions and …
The power of protein interaction networks for associating genes with diseases
S Navlakha, C Kingsford - Bioinformatics, 2010 - academic.oup.com
Motivation: Understanding the association between genetic diseases and their causal genes
is an important problem concerning human health. With the recent influx of high-throughput …
is an important problem concerning human health. With the recent influx of high-throughput …
Spreading dynamics in complex networks
Searching for influential spreaders in complex networks is an issue of great significance for
applications across various domains, ranging from epidemic control, innovation diffusion …
applications across various domains, ranging from epidemic control, innovation diffusion …
Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research
Abstract During the National Neurotrauma Symposium 2010, the DG Research of the
European Commission and the National Institutes of Health/National Institute of …
European Commission and the National Institutes of Health/National Institute of …